small molecules 2012 collection Search Results


small molecules 2012 collection  (Prestwick Chemical)
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Prestwick Chemical small molecules 2012 collection
(A) Screening of the Prestwick chemical library containing <t>1200</t> marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in <t>the</t> <t>CpHK/G6PDH-coupled</t> assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.
Small Molecules 2012 Collection, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Screening of the Prestwick chemical library containing 1200 marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in the CpHK/G6PDH-coupled assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.

Journal: The Journal of eukaryotic microbiology

Article Title: The Action of the Hexokinase Inhibitor 2-deoxy-D-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs

doi: 10.1111/jeu.12690

Figure Lengend Snippet: (A) Screening of the Prestwick chemical library containing 1200 marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in the CpHK/G6PDH-coupled assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.

Article Snippet: Four existing drugs were discovered to possess anti-CpHK activities As a first step to discover new CpHK inhibitors, we screened 1200 small molecules (2012 collection) in the Prestwick Chemical Library using an HK/G6PDH-coupled assay.

Techniques: Positive Control, Biomarker Discovery, Derivative Assay

Inhibition of the CpHK and HsHK1 enzyme activity by the top four hits identified from 1200 existing drugs and their efficacies against the growth of C. parvum in vitro

Journal: The Journal of eukaryotic microbiology

Article Title: The Action of the Hexokinase Inhibitor 2-deoxy-D-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs

doi: 10.1111/jeu.12690

Figure Lengend Snippet: Inhibition of the CpHK and HsHK1 enzyme activity by the top four hits identified from 1200 existing drugs and their efficacies against the growth of C. parvum in vitro

Article Snippet: Four existing drugs were discovered to possess anti-CpHK activities As a first step to discover new CpHK inhibitors, we screened 1200 small molecules (2012 collection) in the Prestwick Chemical Library using an HK/G6PDH-coupled assay.

Techniques: Inhibition, Activity Assay